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From Powder to Tablet: Continuous Processing with ConsiGma

What this video shows

GEA presents ConsiGma, a range of plug flow tableting equipment with which pharmaceutical producers manufacture oral solid dosage forms continuously, from powder to tablet.

What the footage shows

The manufacturer explains its continuous tableting line and the path of the material from powder to finished tablet.

Process challenge

Batch tableting splits production into separate steps with waiting times, intermediate storage and a scale-up step between development and production.

Demonstrated solution

A plug flow line in which granulation, drying and compression follow each other continuously, so the same equipment serves development and production.

Technical overview

Key features

  • •Plug flow tableting equipment for oral solid dosage forms.
  • •Continuous processing from powder through to tablet.
  • •Aims at a shorter development time than the batch route.

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About this video

Batch production of a tablet runs in steps: granulate, dry, blend, compress, each with its own vessel, its own waiting time and its own sampling. Continuous processing puts the same unit operations in a line through which material moves without stopping, and the line is what the product quality is measured on.

This video walks through the ConsiGma concept and shows where the development time and the scale-up step disappear when the same line runs from the first trial batch to production.

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